Benzodiazepine

All posts tagged Benzodiazepine

Fears as tranquilliser addiction rises | Society | The Observer.

This is an older story but it still applies today. Benzo addictions are going up all over the world. Lou

A shortage of heroin has sent users to the equally dangerous drug known as ‘mother’s little helper’

Tablets of diazepam, better known as the tranquilliser Valium

Tablets of diazepam, better known as the tranquilliser Valium, selling illegally at £1 for 10mg among class A drug users. Photograph: Science photo library

They used to be called ‘mother’s little helpers’, pill prescribed to stressed suburban housewives as a miracle pick-me-up. Now benzodiazepines are proving popular again, this time as an alternative to heroin.

The tranquilliser boomed in the Sixties and Seventies as a supposedly safe alternative to barbiturates. Mick Jagger and Keith Richards of the Rolling Stones immortalised it in ‘Mother’s Little Helper’, their 1966 song about a housewife addicted to prescribed drugs because of the pressures of domestic life. Prescriptions peaked at 30 million in 1979, but evidence grew that ‘benzos’ could lead to addiction and horrific withdrawal symptoms, prompting a backlash.

However, their use is on the rise again because heroin is in short supply in some parts of the country or its purity is compromised, according to drugs campaigners. They say that benzos such as diazepam can be far more addictive than heroin and potentially lethal if withdrawn abruptly or mixed with alcohol and methadone. But there is a dire lack of provision for addicts seeking help.

The warning came days after it was revealed that shadow Chancellor George Osborne’s brother, Adam, had been suspended as a junior psychiatrist over allegations that he inappropriately prescribed tranquillisers to his friends. If an investigation by the General Medical Council finds against him, he could be barred from practice.

A recent survey of 100 drug and alcohol services and police forces by the organisation Drugscope found a rise in the use of diazepam – which was first marketed as Valium – by heroin and cocaine users in 15 out of 20 locations around the country. It can be bought for £1 per 10mg tablet and is relatively easy to find online. Dealers are unperturbed by sentences of up to 14 years in prison for handling the pills.

Twenty years ago, the Committee on the Safety of Medicine recommended that benzodiazepines should not be used for more than four weeks at a time, but repeat prescriptions continued. There are an estimated 1.2 million involuntary legal addicts in Britain as well as thousands of illicit users of the class C drug, which was developed by Hoffman-La Roche in the Sixties.

Known as ‘blues’ or ‘vallies,’ diazepam is often used as a substitute for heroin or to ease the comedown from crack cocaine. A massive increase in illegal imports, both genuine and counterfeit, possibly from Spain, Portugal and France, may be behind the trend. Police and customs seizures have risen from 300,000 pills between July 2003 and June 2006 to two million between July 2006 and June 2008.

Barry Haslam, 65, who runs a support group for benzodiazepine addicts in Oldham, once had a 300mg-a-day habit after being prescribed medication following a nervous breakdown. He claims the drug crippled him and stole 10 years of his life as doctors gradually increased his dosage. ‘These drugs are brutal and should be reclassified in the light of research,’ he said. ‘I am extremely mild-mannered but they made me very aggressive and the withdrawals were agonising. I would go out looking for fights; I would punch walls and spent many months of withdrawal in horrific pain. I have seen grown men cry coming off these.’

Abruptly stopping benzodiazepines can also cause fatal seizures. Other withdrawal symptoms include acute anxiety, nausea, vomiting, diarrhoea, insomnia, irritability, headaches, muscle and bone pain and depression. Haslam said: ‘The violence these things can cause is off the chart: people become feral.’

One survey found that every GP surgery in Newcastle upon Tyne had at least 180 long-term users while, nationwide, tranquillisers remain the most commonly prescribed mood altering drug for many conditions from anxiety to back pain and even PMT. Haslam condemned the legal prescription of the drugs by doctors. ‘In my opinion, many of the tranquilliser drug manufacturers make the Colombian drug barons look like rank amateurs and the doctors have become the legal drug pushers,’ he said.

The government is facing calls to take action. Labour minister Phil Woolas said: ‘The story of benzodiazepines has been described as a national scandal. The impact is too big for governments, regulatory authorities and the pharmaceutical industry to address head on, so the scandal has been swept under the carpet. Benzos are responsible for more pain, unhappiness and damage than anything else in our society.’

8 Drug Combinations That Can Really Mess You Up | Drugs | AlterNet.

 AlterNet

Mixing some of these drugs together is a bit like throwing a Molotov cocktail at your own body.
 
 

If you’re reading The Fix, you already know that substances of abuse can make a mess of people’s lives. There are dozens of chemicals that can render you friendless, jobless and despondent—if not outright kill you—all by themselves. That makes mixing them together a bit like throwing a Molotov cocktail at your own body. Too much of drug A may cause liver failure, say. Add a little of drug B and it might happen two hours sooner. Toss in drug C, and maybe you’ll stop breathing before your liver even gets involved.

Because every person reacts slightly differently, there’s virtually no way to determine which drug combination is most likely to land you, personally, in a body bag. But that doesn’t mean some pairings aren’t deadlier than others. Some—like the painkiller/anti-anxiety drug/sleeping pill cocktail that killed Heath Ledger, and has been soaring in drug use stats—terrify even medical professionals.

(* 4. April 1979 in Perth, Western Australia, ...

(* 4. April 1979 in Perth, Western Australia, Australien † 22. Januar 2008 in New York) (Photo credit: Wikipedia)

Based on SAMHSA’s Drug Abuse Warning Network (DAWN) report—and the opinions of Dr. Joseph Lee, medical director of Hazelden’s youth continuum, and Dr. Cynthia Lewis-Younger, managing/medical director at the Florida Poison Information Center – Tampa—here are some of the very worst offenders:

Alcohol Combos

  • 1. Alcohol and benzos

Benzodiazepines were involved in over a fifth of drug- and alcohol-related hospital visits in 2009, according to the DAWN report—and you can bet that respiratory failure was a factor in most cases. The likelihood of this pairing happening in a party setting is an added danger; fellow revelers might be inclined to let the guy who overdid it sleep it off while they carry on having fun. That’s a really bad move, says Dr. Lewis-Younger: “We have a cultural mantra, I guess, in this country about letting people sleep it off. I cannot tell you how many tragedies that I have heard of in my duties that happened because of it.”

  • 2. Alcohol and prescription painkillers

Even though this combo causes slightly fewer hospital visits than mixing drinks with benzos—15% of visits involving alcohol and drugs, versus 21% that involve anxiety drugs—it may be growing in popularity. The number of emergency room trips due to fentanyl, hydrocodone, hydromorphone, morphine, and oxycodone doubled between 2004 and 2009. And if that trend continues, more problems caused by mixing them with alcohol can’t be far behind. What’s worse, this particular combination, like alcohol and benzos, tends to be common among young women (think: Hollywood starlets) who indulge at parties and concerts—and alcohol has stronger effects on women than on men. 

Cocaine Combos

  • 3. Cocaine and opiates

Ah, the dreaded speedball. In the ’80s and ’90s—when this combination felled John Belushi, Chris Farley and River Phoenix—this might have topped the combo list. Don’t get too comfortable though; any drop in prominence is mainly due to the increased popularity of prescription pills. The speedball remains just as dangerous as ever. “So many different things—seizures, heart attacks, strokes, unregulated body temperature—can happen when you take drugs that stimulate you, like cocaine,” says Dr. Lee. “And then, on the other side you have the respiratory depression. If you have a combination of the two, it can make it harder for you to recognize the impact of one chemical.”

  • 4. Cocaine and ecstasy

Just like combining two depressants, combining two stimulants can exacerbate the effects of both. Though you’ll hardly fall asleep and stop breathing on this drug cocktail, you might well stop breathing in another way. Ecstasy on its own can damage the cardiovascular system and cause problems with body temperature regulation, and cocaine can do the same. If you’re dancing at a hot sweaty club or a summer music festival while taking both, you’re pretty much asking to overheat or have a stroke. What’s more, these two drugs frequently come cut; you really have no idea what you’re getting. As Dr. Lewis-Younger puts it, “Combining any unknown with any other unknown? It’s like Russian roulette.”

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8 Drug Combinations That Can Really Mess You Up | Drugs | AlterNet.